The Profectum Foundation and Celebrate the Children School faculties have been providing cutting-edge intervention to children with difficulties in relating and communicating and to their families worldwide for over fifty years combined. At the core of the interventions highlighted in this conference is the understanding that development never stops and that every child’s potential is limitless if you tap into his or her individual learning profile. This conference will provide an overview of the latest insights into the unique profiles and experiences of children and young adults on the autistic spectrum and other developmental and emotional disorders. A comprehensive overview of the application of evidenced-based developmental practices in the classroom will be presented by teachers, occupational therapists, physical therapists, speech-language pathologists and mental health professionals working in both private and public school settings in the United States and abroad. Program components that promote regulation, sensory motor development, visual-spatial capacities, engagement, intentionality, problem solving, symbolic and abstract thinking will be illustrated through classroom video examples. Teachers and therapists use affective, emotionally meaningful, experience-based activities tailored to the individual needs of the students to maximize motivation, comprehension and retention of knowledge. The principle of “discovery vs. teaching” is emphasized as teachers and therapists promote thinking vs. memorization in the classroom. Case studies will be used to demonstrate how children with developmental challenges can build strong relationships and become creative, global thinkers who are prepared for the 21st century. The integration of the use of technology to maximize participation and communication will also be incorporated.